Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight

NCT07770841 · Recruiting

Last updated 2026-09-22

This study is testing how well an oral medication called semaglutide helps adults with excess body weight lose weight.

Status Recruiting Currently enrolling participants.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, quadruple-blind treatment study

Participants 450 people Planned (estimated).

Who can join Ages 18+ · all sexes

Timeline Started 2026-08 · est. completion 2028-04

Where 62 sites · Belgium, Bulgaria, Denmark, France, Greece, Netherlands, Poland, Spain, Sweden, United States

What this study is testing ClinicalTrials.gov NCT07770841 ↗

Description as written by the study sponsor.

The purpose of this study is to see how oral semaglutide, when taken in lower doses help lowering of body weight in participants with excess body weight when compared to 'dummy' tablets (placebo). Results from this study will help select the most optimal lower dose of oral semaglutide that can be used for treating participants living with overweight or obesity.

Treatments tested

Semaglutide Drug

Participants will receive semaglutide orally.
Placebo Drug

Participants will receive placebo orally.

Main thing measured	Relative change in body weight
Sponsor	Novo Nordisk A/S
Conditions studied	Overweight, Obesity
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT07770841 ↗