Genetic, Microbiological and Behavioral Factors in Obesity

NCT07650149 · Recruiting

Last updated 2026-07-14

This clinical trial examines genetic, microbiological, and behavioral factors related to weight change in adults with obesity or overweight.

Status Recruiting Currently enrolling participants.

Type Observational

Participants 200 people Planned (estimated).

Who can join Ages 18–60 · all sexes

Timeline Started 2026-05 · est. completion 2028-05

Where 2 sites · Poland

What this study is testing ClinicalTrials.gov NCT07650149 ↗

Description as written by the study sponsor.

This study will assess the impact of genetic markers, microbiological (microbiome) and behavioral factors on tolerance, adherence and effectiveness of dual GLP1/GIP RA in the treatment of obesity. 200 consecutive patients who meet all inclusion and none of the exclusion criteria will be enrolled.

Treatments tested

genetic polymorphism Diagnostic test

GLP1 RA and GIP R polymorphisms will be assesed from venous blood samples
gut microbiome Diagnostic test

stool samples and oral cavity swabs for gut microbiome will be collected to assess V3 and V4 of gene 16s rRNA

Main thing measured	weight change
Sponsor	Jan Kochanowski University
Conditions studied	Obesity & Overweight, Obesity, Genetics
GLP-1 drugs	—

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT07650149 ↗