Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)

What this study is testing ClinicalTrials.gov NCT07547878 ↗

Description as written by the study sponsor.

The goal of this clinical trial is to learn if starting four kidney disease medicines quickly and together (a rapid treatment approach) is safe and works well in people with type 2 diabetes and chronic kidney disease. The main questions it aims to answer are: * Is it safe to start these medicines over a short period of time? * How often do kidney function changes or high potassium levels occur? * Does this approach lower protein in the urine (a sign of kidney damage)? * How many participants are able to stay on all four medicines over 6 months? Researchers will compare this approach to usual care, where medicines are started one at a time over several months. Participants will: Be assigned by chance to either this approach or usual care Start up to four approved kidney medicines over about 8 weeks (rapid treatment approach) or follow standard care Have regular clinic visits and lab tests to check kidney function and potassium levels Be followed for about 6 months

Treatments tested

• Finerenone Drug

  10-40mg daily

• Semaglutide Drug

  .25-1.0mg 1 time a week

• Lotensin also known as Benazepril Drug

  10-40mg daily

• Capoten also known as Capotopril Drug

  12.5-50mg 3 times a day

• Enalapril Drug

  2.5-10mg daily

• Monopril also known as Fosinopril Drug

  10-40mg daily

• Lisinopril Drug

  5-20mg daily

• Univasc also known as Moexipril Drug

  3.75-15mg daily

• Aceon also known as Perindopril Drug

  4-16mg daily

• Accupril also known as Quinapril Drug

  10-40mg daily

• Altace also known as Ramipril Drug

  1.25-5mg daily

• Mavik also known as Trandolapril Drug

  1-4mg daily

• Edarbi also known as Azilsartan Drug

  40-80mg daily

• Atacand also known as Candesartan Cilexetil Drug

  8-32mg daily

• Avapro also known as Irbesartan Drug

  150-300mg daily

• Cozaar also known as Losartan Drug

  25-100mg daily

• Benicar also known as Olmesartan Drug

  20-40mg daily

• Micardis also known as Telmisartan Drug

  20-80mg daily

• Diovan also known as Valsartan Drug

  80-320mg daily

• Invokana also known as Canagliflozin Drug

  100mg daily

• Farxiga also known as Dapagliflozin Propanediol Drug

  10mg daily

• Jardiance also known as Empagliflozin Drug

  10mg daily

• Ertugliflozin Drug

  5mg daily

• Brenzavvy also known as Bexagliflozin Drug

  20mg daily

• Sotagliflozin also known as SAR439954 Drug

  200-400mg daily