The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED)

What this study is testing ClinicalTrials.gov NCT07298915 ↗

Description as written by the study sponsor.

This is clinical trials is to evaluate the effect of exercise with weight loss medication compared to weight loss alone. The study will enroll 24 adults from 30-65 years old with overweight or obesity. The main questions it will answer includes: * Does exercise combined with weight loss medication reduce body weight and body fat more than weight loss medication alone * Does exercise combined with weight loss medication improve other risk factors more such as the sugar in the blood, cholesterol, fitness, and quality of life Participants will: * Take a weight loss medication (tirzepatide) monthly under the supervision of their primary care physician * (Exercise group only) Will perform exercise \~3 times a week at the University of Virginia). Walking on a treadmill and resistance training * Visit the study site at the beginning of the study and after the study to evaluate weight, body fat, and other health measures

Treatments tested

• Tirzepatide Drug

  Participants will take tirzepatide under the care of their primary care provider for 16 weeks

• Exercise Behavioral

  Participants will perform a combination of aerobic and resistance training for 16 weeks