Effect of Itopride on Semaglutide Gastroparesis

NCT07254715 · Recruiting

Last updated 2026-05-28

This clinical trial is testing whether itopride can help people experiencing slowed stomach emptying caused by semaglutide.

Status Recruiting Currently enrolling participants.

Phase Phase 4 Monitors a drug already on the market.

Type Interventional (clinical trial)

Design Randomized, quadruple-blind prevention study

Participants 60 people Planned (estimated).

Who can join Ages 40–60 · female only

Timeline Started 2025-12 · est. completion 2026-04

Where 1 site · Egypt

What this study is testing ClinicalTrials.gov NCT07254715 ↗

Description as written by the study sponsor.

Semaglutide delays gastric emptying and increases the risk of aspiration with anesthesia; So, the addition of prokinetics as Itopride, could enhance gastric emptying and hasten surgery. The investigator will evaluate the effect of Itopride on Semaglutide-induced gastroparesis and residual gastric contents after 8 hours of fasting by gastric ultrasound before anesthesia.

Treatments tested

Itopride HCI 50 mg Drug

Daily oral 50mg Itopride tablet TID, 1 hour before meals for 7 days
Placebo Drug

Daily placebo tablet TID, 1 hour before meals for 7 days

Main thing measured	Residual gastric contents
Sponsor	Ain Shams University
Conditions studied	Semaglutide-Induced Gastric Motility, Anesthesia
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT07254715 ↗