Tailored Exercise Training Study Among Adults With HFpEF

What this study is testing ClinicalTrials.gov NCT07223242 ↗

Description as written by the study sponsor.

Heart failure with preserved ejection fraction (HFpEF) is associated with a high morbidity and mortality burden. There are limited pharmacological options available for the treatment of HFpEF. Exercise intolerance (EI) is the cardinal symptom of HFpEF, which manifests as dyspnea and fatigue. EI leads to functional deconditioning and reduced quality of life (QOL), both of which elevate risk of death and hospitalization in patients with HFpEF. Supervised exercised training is associated with improvements in exercise capacity and QOL in adults with HFpEF. However, supervised exercise has not been widely utilized for the treatment of HFpEF due to logistical and fiscal barriers. This study will investigate the effects of a remote exercise training intervention on exercise capacity and skeletal muscle composition in patients with HFpEF, or those at risk for it. In addition, it will compare four different lifestyle interventions for their effects on exercise capacity.

Treatments tested

• Moderate-intensity continuous training (MCT) Behavioral

  Tailored moderate-intensity exercise training video with weekly virtual meetings with a coach

• Resistance training Behavioral

  Resistance training videos assigned to patient

• Weight loss Drug

  Initiation/intensification of weight loss medications, such as semaglutide or tirzepatide