Rebalancing the Fat Content of the Heart and Muscles

NCT07065383 · Recruiting

Last updated 2026-05-28

This clinical trial is testing whether changing the fat content in the heart and muscles, measured by a special imaging technique, can help people with type 2 diabetes.

Status Recruiting Currently enrolling participants.

Phase Not applicable Not a phased drug trial (e.g. a device or behavioral study).

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) basic-science study

Participants 60 people Planned (estimated).

Who can join Ages 20–75 · all sexes

Timeline Started 2025-08 · est. completion 2028-07

Where 1 site · United Kingdom

What this study is testing ClinicalTrials.gov NCT07065383 ↗

Description as written by the study sponsor.

Traditional diabetes therapies focus on improving blood sugar control. However, many studies show that this may not be enough. New treatments focusing on weight loss have heralded better results. One of these treatments is Semaglutide and the investigators wish to examine its effects further in this study. The investigators propose to investigate what happens to the fat inside the heart and the leg muscles.

Treatments tested

Semaglutide administration plus dietary counselling and physical activity encouragement also known as Semaglutide with dietary counselling and physical activity encouragement Drug

Semaglutide administration plus dietary counselling and physical activity encouragement
Semaglutide plus a personalised and supervised program of resistance and endurance training also known as Semaglutide plus personalised and supervised resistance and endurance training program Drug

Semaglutide administration plus a personalised and supervised program of resistance and endurance training.

Main thing measured	1H-magnetic resonance spectroscopy
Sponsor	University of Aberdeen
Conditions studied	Diabetes Mellitus Type 2
GLP-1 drugs	—

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT07065383 ↗