Gastric Emptying in Healthy Volunteers and GLP-1 Agonist Users

NCT06987669 · Not yet recruiting

Last updated 2026-05-28

This clinical trial compares how quickly the stomach empties in healthy volunteers versus people with type 2 diabetes or obesity who use GLP-1 agonists.

Status Not yet recruiting Approved but enrollment has not started.

Type Observational

Participants 155 people Planned (estimated).

Who can join Ages 18+ · all sexes Healthy volunteers accepted.

Timeline Started 2025-05 · est. completion 2027-12

What this study is testing ClinicalTrials.gov NCT06987669 ↗

Description as written by the study sponsor.

This observational study aims to determine the gastric emptying kinetics assessed by ultrasound in healthy volunteers after a standard breakfast and the state of the stomach after a clear liquid diet for 18 /24 hours in patients on GLP-1 agonist. The main questions it seeks to answer are: * Is the kinetic after a standard breakfast that includes ( avocado and eggs: high fat) as fast as a standard meal that does not involve this food? * Is a clear liquid diet of 18 to 24 hours enough to be an empty-stomach, assessed by Ultrasound in patients on GLP1 agonist? Participants will be asked to do: -A baseline Gastric US will be performed for healthy volunteers, and then they will have a standardized breakfast. An hourly or bihourly assessment will be done by the US.

Treatments tested

Gastric Ultrasound also known as GUS Diagnostic test

A gastric ultrasound will be performed to determine the state of the stomach. Empty, clear fluids, solid, and in case of fluid, the amount of it ( using free tracing)

Main thing measured	Number of patients with each Grade ( stomach content characteristics) according Perlas et al
Sponsor	Clinica Alemana de Santiago
Conditions studied	Diabetes Type 2, Obesity and Overweight
GLP-1 drugs	—

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT06987669 ↗