Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease

What this study is testing ClinicalTrials.gov NCT06976853 ↗

Description as written by the study sponsor.

The purpose of this research study is to evaluate what type of treatment will be beneficial for people with Crohn's disease and difficult to treat inflammation in the small bowel. Current therapies are used to control the inflammation due to Crohn's disease in your digestive tract. In some patients, those therapies are not sufficient to fully treat the disease. This objective of this study is to evaluate the efficacy of a different type of therapy, tirzepatide, that may promote healing of the affected intestinal segment. To evaluate the efficacy of this medication, a member of the research team will ask patients questions about how they feel and observe whether this medication heals the their bowel at colonoscopy. A member of the research team will also use blood samples, stool samples and samples of the small intestine taken during a colonoscopy to understand how tirzepatide helps heal the intestine.

Treatments tested

• Tirzepatide Drug

  Addition of tirzepatide to current biological therapy

• Standard of care treatment Drug

  Intervention will be to change patient's current therapy to a 3rd or later advanced biologic patient have never been exposed to