Impact of Bariatric Surgery and Liraglutide on Cognitive-Behavioral Markers of Long-Term Weight Loss in Obesity

NCT06720246 · Recruiting

Last updated 2026-05-28

This clinical trial tests how bariatric surgery and the medication liraglutide affect thinking and behavior related to weight loss in adults with obesity or overweight.

Status Recruiting Currently enrolling participants.

Type Observational

Participants 50 people Planned (estimated).

Who can join Ages 20–60 · all sexes

Timeline Started 2024-06 · est. completion 2027-05

Where 1 site · Italy

What this study is testing ClinicalTrials.gov NCT06720246 ↗

Description as written by the study sponsor.

The present research project aims to study the effects of bariatric surgery and liraglutide administration (in patients already selected for one of these procedures) on two cognitive-behavioral processes partially supported by distinct brain networks: automatic approach tendencies (underpinned by the cue-reactivity network) and behavioral inhibition (underpinned by the cue-regulation network). Additionally, the investigators aim to study how these processes may be modulated by satiety. The secondary objective of the project includes identifying cognitive-behavioral markers that can predict the response to these treatments.

Main thing measured	Reaction times (approach bias)
Sponsor	I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Conditions studied	Obesity and Overweight
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT06720246 ↗