Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy

NCT06533527 · Completed

Last updated 2026-05-28

This clinical trial is testing whether stopping or continuing certain diabetes medications before an upper endoscopy affects stomach contents in adults with type 2 diabetes, obesity, or gastroparesis.

Status Completed The study has finished.

Phase Phase 4 Monitors a drug already on the market.

Type Interventional (clinical trial)

Design Randomized, double-blind health-services study

Participants 69 people

Who can join all sexes Healthy volunteers accepted.

Timeline Started 2024-07 · est. completion 2025-05

Where 2 sites · United States

What this study is testing ClinicalTrials.gov NCT06533527 ↗

Description as written by the study sponsor.

To assess whether holding incretin-based therapy before endoscopy reduces the likelihood of clinically relevant Residual Gastric Volume (RGV). Primary Outcomes: * Residual gastric volume that precludes adequate endoscopic examination * Residual gastric volume that necessitates premature termination of the endoscopy procedure * Need for endotracheal intubation due to stomach contents. * Occurrence of aspiration events requiring extended observation/monitoring, unplanned therapeutics, and/or hospital admission Secondary Outcomes: * Presence of any solid food * Presence of moderate liquid content * Increased RGV(Residual Gastric Volume) defined as any amount of solid content or \> 0.8 mL/Kg of fluid content (measured from the aspiration/suction canister). * Differences in primary and secondary outcomes between different medications

Treatments tested

GLP-1 medication also known as Tirzepatide, Semaglutide, Liraglutide, Dulaglutide Drug

Continue taking GLP-1 as normally scheduled prior to endoscopy.

Main thing measured	Presence of RGV (Residual Gastric Volume) in Stomach
Sponsor	The Cleveland Clinic
Conditions studied	Diabetes Mellitus, Type 2, Obesity, Gastroparesis
GLP-1 drugs	—

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT06533527 ↗