Semaglutide Therapy for Alcohol Reduction - Tulsa

NCT05891587 · Completed

Last updated 2026-05-28

This clinical trial is testing whether semaglutide, a medication, can help reduce alcohol consumption in adults with alcohol use disorder.

Status Completed The study has finished.

Phase Phase 2 Tests whether it works and watches safety in a moderate group.

Type Interventional (clinical trial)

Design Randomized, triple-blind treatment study

Participants 80 people

Who can join Ages 18+ · all sexes

Timeline Started 2023-07 · est. completion 2025-10

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT05891587 ↗

Description as written by the study sponsor.

The purpose of this research study is to determine if semaglutide, when compared to placebo, is safe and may reduce alcohol drinking in individuals who endorse symptoms consistent with alcohol use disorder.

Treatments tested

Semaglutide Drug

Semaglutide pen injector
Placebo Drug

Saline solution

Main thing measured	Change in alcohol drinks per drinking day.
Sponsor	Oklahoma State University Center for Health Sciences
Conditions studied	Alcohol Use Disorder
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT05891587 ↗