Perioperative Stress Hyperglycemia in General and Vascular Surgery Patients

What this study is testing ClinicalTrials.gov NCT04862234 ↗

Description as written by the study sponsor.

Hyperglycemia is seen in approximately 30% of patients who do not have a history of diabetes and undergo general surgery. Hyperglycemia in this setting is associated with increased risk of postoperative complications. The purpose of this study is to investigate risk factors for developing high sugars during the time of surgery, and if these high sugars can be prevented by the use of an injectable diabetes medication (dulaglutide) prior to surgery.

Treatments tested

• Dulaglutide also known as Trulicity Drug

  A subcutaneous injection of dulaglutide 0.75 mg will be administered within 72 hours prior to a planned surgical intervention.

• Placebo Drug

  A subcutaneous injection of a saline placebo will be administered within 72 hours prior to a planned surgical intervention.

• Continuous glucose monitor (CGM), blinded also known as FreeStyle Libre Pro Device

  Continuous glucose monitor (CGM) sensor will be placed preoperatively and continued during surgical hospitalization to monitor glucose levels. CGM provides an estimated capillary blood glucose (BG) level through direct measurement of interstitial glucose levels every 5-15 minutes.