A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo)

NCT04093752 · Completed

Last updated 2026-05-28

This clinical trial is testing the medication tirzepatide in adults with type 2 diabetes who are already taking metformin, with or without a sulfonylurea.

Status Completed The study has finished.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) treatment study

Participants 917 people

Who can join Ages 18+ · all sexes

Timeline Started 2019-12 · est. completion 2021-11

Where 67 sites · Australia, China, India, South Korea

What this study is testing ClinicalTrials.gov NCT04093752 ↗

Description as written by the study sponsor.

The main reason for this study is to compare the study drug tirzepatide to insulin glargine in participants with type 2 diabetes on metformin with or without a sulfonylurea.

Treatments tested

Tirzepatide also known as LY3298176 Drug

Administered SC
Insulin Glargine Drug

Administered SC

Main thing measured	Mean Change From Baseline in Hemoglobin A1c (HbA1c) (10 mg and 15 mg)
Sponsor	Eli Lilly and Company
Conditions studied	Type 2 Diabetes
GLP-1 drugs	tirzepatide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT04093752 ↗