Short Term Weight Loss With Liraglutide and Metformin in Infertile Obese PCOS Patients

NCT03034941 · Completed

Last updated 2026-05-28

This clinical trial tested whether the medications liraglutide and metformin could help reduce weight in women with obesity and polycystic ovary syndrome (PCOS) who are also infertile.

Status Completed The study has finished.

Phase Phase 4 Monitors a drug already on the market.

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) treatment study

Participants 35 people

Who can join Ages 18–38 · female only

Timeline Started 2014-04 · est. completion 2016-12

Where 1 site · Slovenia

What this study is testing ClinicalTrials.gov NCT03034941 ↗

Description as written by the study sponsor.

The aim of this study was to evaluate the impact of short-term weight reduction achieved with 12-week intervention with metformin alone or in combination with liraglutide on oocyte maturity and embryo quality in infertile obese PCOS population.

Treatments tested

Metformin also known as Glucophage tablets Drug

In the metformin group metformin was initiated at a dose of 500 mg once per day and increased by 500 mg every 3 days up to 1000 mg twice per day per os for 12 weeks
Liraglutide + metformin also known as Victoza 6 mg/ml solution and Glucophage tablets Drug

In the COMBI group the initial dose of metformin was 500 mg for at least 2 wk and gradually increased to a final dose of 1000 mg twice per day. Liraglutide 1.2 mg once per day s.c. was added after first two weeks of monotherapy with metformin.

Main thing measured	The main outcome was change in BMI
Sponsor	University Medical Centre Ljubljana
Conditions studied	Obesity, PCOS
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT03034941 ↗