Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance

NCT02928679 · Completed

Last updated 2026-05-28

This clinical trial tests whether weight maintenance affects knee inflammation in obese adults with knee osteoarthritis using advanced imaging techniques.

Status Completed The study has finished.

Phase Phase 4 Monitors a drug already on the market.

Type Interventional (clinical trial)

Design Randomized, quadruple-blind treatment study

Participants 150 people Planned (estimated).

Who can join Ages 18–74 · all sexes

Timeline Started 2016-11 · est. completion 2019-03

Where 1 site · Denmark

What this study is testing ClinicalTrials.gov NCT02928679 ↗

Description as written by the study sponsor.

This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864). In the parent trial, patients will be subjected to an 8-week diet intervention phase including a low-calorie diet and dietetic counseling, after which patients will be randomised to receive either liraglutide 3 mg or liraglutide 3 mg placebo as an add-on to dietetic guidance on re-introducing regular foods and a focus on continued motivation to engage in a healthy lifestyle. This substudy aims to investigate the impact of, and subsequent change of, joint inflammation, articular cartilage composition, overall knee morphology, and clinical symptoms, in obese patients with knee osteoarthritis following a randomisation to Liraglutide 3 mg or Liraglutide 3 mg placebo treatment between weeks 0-52.

Treatments tested

Liraglutide 3 mg (Saxenda) Drug
Liraglutide 3 mg placebo Drug

Main thing measured	Change in the degree of inflammation in the knee-joint (DCE-MRI)
Sponsor	Henrik Gudbergsen
Conditions studied	Osteoarthritis, Obesity
GLP-1 drugs	—

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02928679 ↗