A Double-blinded Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide and Insulin Degludec Both in Combination With Metformin in Japanese Subjects With Type 2 Diabetes Mellitus Inadequately Controlled With Basal or Pre-mix/Combination Insulin Therapy and Oral Anti-diabetic Drugs

NCT02911948 · Completed

Last updated 2026-05-28

This clinical trial compares two diabetes treatments—insulin degludec/liraglutide and insulin degludec, both combined with metformin—in Japanese adults with type 2 diabetes whose blood sugar is not well controlled by current insulin and oral medications.

Status Completed The study has finished.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, double-blind treatment study

Participants 210 people

Who can join Ages 20+ · all sexes

Timeline Started 2016-09 · est. completion 2017-11

Where 38 sites · Japan

What this study is testing ClinicalTrials.gov NCT02911948 ↗

Description as written by the study sponsor.

This trial is conducted in Asia. The aim of this trial is to compare the efficacy and safety of insulin degludec/liraglutide and insulin degludec both in combination with metformin in Japanese subjects with type 2 diabetes mellitus inadequately controlled with basal or pre-mix/combination insulin therapy and oral anti-diabetic drugs.

Treatments tested

Insulin degludec/liraglutide Drug

Injected s.c. / subcutaneously (under the skin) once daily
Insulin degludec Drug

Injected s.c. / subcutaneously (under the skin) once daily

Main thing measured	Change in Glycosylated Haemoglobin (HbA1c)
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02911948 ↗