Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus

NCT02863419 · Completed

Last updated 2026-05-28

This clinical trial tested the effects of an oral diabetes medication called semaglutide compared to another diabetes medication called liraglutide and a placebo in adults with type 2 diabetes.

Status Completed The study has finished.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, double-blind treatment study

Participants 711 people

Who can join Ages 18+ · all sexes

Timeline Started 2016-08 · est. completion 2018-03

Where 108 sites · Croatia, Czechia, Germany, Hungary, Japan, Latvia, Poland, Puerto Rico, Slovakia, South Africa, Ukraine, United Arab Emirates, United States

What this study is testing ClinicalTrials.gov NCT02863419 ↗

Description as written by the study sponsor.

This trial is conducted globally. The aim of this trial is to investigate efficacy and safety of oral Semaglutide versus Liraglutide and versus Placebo in Subjects with Type 2 Diabetes Mellitus.

Treatments tested

semaglutide Drug

Oral semaglutide once-daily.
liraglutide Drug

Subcutaneous (s.c.) injection once-daily.
placebo Drug

Placebo once-daily.

Main thing measured	Change in HbA1c (Week 26)
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	semaglutide, liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02863419 ↗