Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus

NCT02863328 · Completed

Last updated 2026-05-28

This clinical trial compared the effects of an oral diabetes medication called semaglutide to another medication called empagliflozin in adults with type 2 diabetes.

Status Completed The study has finished.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) treatment study

Participants 822 people

Who can join Ages 18+ · all sexes

Timeline Started 2016-08 · est. completion 2018-03

Where 106 sites · Argentina, Brazil, Croatia, Greece, Hungary, Italy, Poland, Russia, Serbia, Spain, Thailand, United States

What this study is testing ClinicalTrials.gov NCT02863328 ↗

Description as written by the study sponsor.

This trial is conducted globally. The aim of this trial is to investigate Efficacy and Safety of Oral Semaglutide versus Empagliflozin in Subjects with Type 2 Diabetes Mellitus.

Treatments tested

semaglutide Drug

Oral administration once-daily.
empagliflozin Drug

Oral administration once-daily.

Main thing measured	Change in HbA1c
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02863328 ↗