Efficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 Diabetes

NCT02607865 · Completed

Last updated 2026-05-28

This clinical trial tested the effects of oral semaglutide compared to sitagliptin in adults with type 2 diabetes to see how well each medication lowered blood sugar over 26 weeks.

Status Completed The study has finished.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, double-blind treatment study

Participants 1,864 people

Who can join Ages 18+ · all sexes

Timeline Started 2016-02 · est. completion 2018-03

Where 242 sites · Argentina, Brazil, France, Germany, India, Israel, Japan, Mexico, Romania, Russia, South Africa, Turkey (Türkiye), Ukraine, United Kingdom, United States

What this study is testing ClinicalTrials.gov NCT02607865 ↗

Description as written by the study sponsor.

This trial is conducted globally. The aim of the trial is to investigate efficacy and long-term safety of oral semaglutide versus sitagliptin in subjects with type 2 diabetes.

Treatments tested

semaglutide Drug

Oral administration once-daily
sitagliptin Drug

Oral administration once-daily
placebo Drug

Oral administration once-daily

Main thing measured	Change in HbA1c: Week 26
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02607865 ↗