The Effect of Liraglutide on Dietary Lipid Induced Insulin Resistance in Humans

NCT02403284 · Completed

Last updated 2026-05-28

This clinical trial tests whether the medication liraglutide affects insulin resistance in people with insulin resistance by measuring how the body responds to insulin after consuming a high-fat diet.

Status Completed The study has finished.

Phase Phase 4 Monitors a drug already on the market.

Type Interventional (clinical trial)

Design Randomized, quadruple-blind basic-science study

Participants 97 people

Who can join Ages 40–75 · all sexes

Timeline Started 2013-03 · est. completion 2023-11

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT02403284 ↗

Description as written by the study sponsor.

In this research study, investigators will test the effects of an approved medication for diabetes,Liraglutide, to reduce insulin resistance that develops from eating a diet high in saturated fats.

Treatments tested

Liraglutide also known as Victoza Drug

Subcutaneous injection by patient
Sugar Pill also known as Placebo Drug

Subcutaneous injection daily

Main thing measured	Whole Body Insulin Sensitivity (insulin suppression test)
Sponsor	Phoenix VA Health Care System
Conditions studied	Insulin Resistance
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02403284 ↗