Effect of Food on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects

NCT02172313 · Completed

Last updated 2026-05-28

This clinical trial tested how eating food affects the levels of semaglutide in the bloodstream of healthy adults.

Status Completed The study has finished.

Phase Phase 1 Checks safety and dosing in a small group.

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) treatment study

Participants 78 people

Who can join Ages 18–75 · all sexes Healthy volunteers accepted.

Timeline Started 2014-06 · est. completion 2014-10

Where 1 site · Germany

What this study is testing ClinicalTrials.gov NCT02172313 ↗

Description as written by the study sponsor.

This trial is conducted in Europe. The aim of the trial is to investigate the effect of food on the pharmacokinetics (the exposure of the trial drug in the body) of oral semaglutide, in a SNAC (sodium N-\[8-(2-hydroxybenzoyl) amino\] caprylate) tablet formulation with three different dosing conditions in healthy subjects.

Treatments tested

semaglutide Drug

For oral administration.

Main thing measured	Area under the semaglutide plasma concentration time curve
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Healthy
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02172313 ↗