Liver and Fat Regulation in Overweight Adolescent Girls

NCT02157974 · Completed

Last updated 2026-05-28

This clinical trial is testing how diet and exercise affect liver function and fat levels in overweight teenage girls with liver fat buildup, polycystic ovary syndrome, or obesity.

Status Completed The study has finished.

Phase Phase2, Phase3

Type Interventional (clinical trial)

Design Non-randomized, open-label (no blinding) study

Participants 92 people

Who can join Ages 12–21 · female only Healthy volunteers accepted.

Timeline Started 2014-08 · est. completion 2022-12

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT02157974 ↗

Description as written by the study sponsor.

Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance. The investigators will assess hepatic glucose release, rates of lipolysis and hepatic de novo lipogenesis in the fasted and postprandial state to determine if alterations in the processes contribute to hepatic steatosis. Participants will be overweight, sedentary girls with or without PCOS. Those with PCOS will either be medication naive, or must be taking metformin or combined oral contraceptives (COCPs) for a period of at least 6 months prior to study procedures.

Treatments tested

Byetta 5Mcg Pen Injection also known as Exenatide Drug

10 participants will receive 2 doses of Byetta, one at 7 PM the night prior to metabolic study and the second 30 min before ingestion of glucola

Main thing measured	Hepatic Glucose Release
Sponsor	University of Colorado, Denver
Conditions studied	Hepatic Steatosis, Polycystic Ovarian Syndrome, Obesity
GLP-1 drugs	—

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02157974 ↗