Effects of Liraglutide on Hippocampal Structure and Function in Aging Adults With Prediabetes

NCT02140983 · Completed

Last updated 2026-05-28

This clinical trial is testing whether the medication liraglutide affects brain structure and thinking abilities in older adults with prediabetes.

Status Completed The study has finished.

Phase Phase 1 Checks safety and dosing in a small group.

Type Interventional (clinical trial)

Design Randomized, triple-blind study

Participants 41 people

Who can join Ages 50–70 · all sexes Healthy volunteers accepted.

Timeline Started 2013-08 · est. completion 2017-02

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT02140983 ↗

Description as written by the study sponsor.

The purpose of this study is to evaluate the effects of liraglutide on the memory and attention of people with insulin resistance. Liraglutide is a medication that makes the body more sensitive to insulin, and therefore may allow it to manage sugar more effectively. The investigators are looking specifically at a region of the brain that is associated with memory and attention, called the hippocampus, in order to see whether treatment this treatment will change performance on memory and attention tasks. The investigators are also taking an MRI of the brain to see whether there are changes to the size and shape of the hippocampus after treatment. All subjects in this study will be 50-70 years old and have pre- diabetes. Half of all subjects will have a family history of dementia, while the other half will not.

Treatments tested

Liraglutide also known as Victoza Drug

90 days of liraglutide up to 1.8mg/day.
Placebo Drug

Placebo medication

Main thing measured	Cognitive Outcomes
Sponsor	Stanford University
Conditions studied	Insulin Resistance, Dementia
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02140983 ↗