Multiple Dose Trial Examining Dose Range, Escalation and Efficacy of Oral Semaglutide in Subjects With Type 2 Diabetes

NCT01923181 · Completed

Last updated 2026-05-28

This clinical trial tested different doses of an oral medication called semaglutide in adults with type 2 diabetes to see how it affects blood sugar levels over time.

Status Completed The study has finished.

Phase Phase 2 Tests whether it works and watches safety in a moderate group.

Type Interventional (clinical trial)

Design Randomized, double-blind treatment study

Participants 632 people

Who can join Ages 18+ · all sexes

Timeline Started 2013-12 · est. completion 2014-12

Where 103 sites · Austria, Bulgaria, Canada, Denmark, Germany, Israel, Italy, Malaysia, Serbia, South Africa, Spain, Sweden, United Kingdom, United States

What this study is testing ClinicalTrials.gov NCT01923181 ↗

Description as written by the study sponsor.

This trial is conducted globally. The aim of the trial is to examine the dose range, escalation and efficacy of oral semaglutide in subjects with type 2 diabetes.

Treatments tested

semaglutide Drug

Once-daily oral administration as tablets.
semaglutide Drug

Once-weekly,injected s.c./subcutaneously (under the skin) using a pen
oral placebo Drug

Once-daily oral administration as tablets.

Main thing measured	Change in HbA1c (Glycosylated Haemoglobin)
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT01923181 ↗