Effects of Liraglutide on Kidney Function in Type 2 Diabetic Patients

NCT01664676 · Completed

Last updated 2026-05-28

This clinical trial tested the effects of the medication liraglutide on kidney function in adults with type 2 diabetes.

Status Completed The study has finished.

Phase Phase 4 Monitors a drug already on the market.

Type Interventional (clinical trial)

Design Randomized, double-blind treatment study

Participants 11 people

Who can join Ages 20–60 · male only

Timeline Started 2012-12 · est. completion 2014-02

Where 1 site · Denmark

What this study is testing ClinicalTrials.gov NCT01664676 ↗

Description as written by the study sponsor.

Recent studies in rodents show that glucagon-like peptide-1 (GLP-1) analogues protect against diabetic nephropathy. We hypothesise that this is also the case in humans. This study will investigate the short-term effect of liraglutide (GLP-1 analogue) on the kidneys in type 2 diabetic patients. Impact on basic kidney physiological will be determined and kidney injury markers will be measured as surrogate parameters of kidney protection.

Treatments tested

Liraglutide also known as Victoza Drug
Placebo-liraglutide also known as Isotonic saline Drug

Main thing measured	Glomerular Filtration Rate (51Cr-EDTA plasma clearance)
Sponsor	University of Aarhus
Conditions studied	Type 2 Diabetes Mellitus
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT01664676 ↗