Acute Effect of Exenatide on Brain Glucose Metabolism

NCT01588418 · Completed

Last updated 2026-05-28

This clinical trial tested how a medication called Exenatide affects brain glucose metabolism in adults with impaired glucose tolerance or diabetes.

Status Completed The study has finished.

Phase Phase 4 Monitors a drug already on the market.

Type Interventional (clinical trial)

Design Randomized, quadruple-blind basic-science study

Participants 15 people

Who can join Ages 18–65 · male only

Timeline Started 2010-07 · est. completion 2015-07

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT01588418 ↗

Description as written by the study sponsor.

This research study will examine brain glucose metabolism after an overnight fast to determine the effect of exenatide on brain glucose metabolism and lipid metabolism.

Treatments tested

Exenatide also known as Byetta Drug

Exenatide (5mcg) was administered in random order 30 min before OGTT-PET study, crossover study
Placebo Drug

Placebo was administered in random order 30 min before OGTT-PET study in the same subject

Main thing measured	Effect of Exenatide on Brain (Total Gray Matter) Glucose Metabolism
Sponsor	The University of Texas Health Science Center at San Antonio
Conditions studied	Impaired Glucose Tolerance (IGT), Diabetes
GLP-1 drugs	exenatide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT01588418 ↗