Comparison of Three Liraglutide Formulations in Healthy Volunteers

NCT01514487 · Completed

Last updated 2026-05-28

This clinical trial compares three different forms of the medication liraglutide in healthy volunteers to study how the body absorbs and processes each version.

Status Completed The study has finished.

Phase Phase 1 Checks safety and dosing in a small group.

Type Interventional (clinical trial)

Design Randomized, double-blind treatment study

Participants 24 people

Who can join Ages 18–50 · all sexes

Timeline Started 2005-01 · est. completion 2005-03

Where 1 site · Australia

What this study is testing ClinicalTrials.gov NCT01514487 ↗

Description as written by the study sponsor.

This trial is conducted in Oceania. The aim of this trial is to test for bioequivalence between each of the two new liraglutide formulations at pH 7.9 and 8.15 and the planned Phase 3 formulation at pH 7.7.

Treatments tested

liraglutide Drug

One single dose of 0.75 mg administered on three different dosing occasions with a 14-day wash-out period between each dosing. Injected subtaneously

Main thing measured	Area under the Curve (0-t)
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Healthy
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT01514487 ↗