Examination of the Effects of Liraglutide on the Mode of Action of Insulin Detemir

NCT00873223 · Completed

Last updated 2026-05-28

This clinical trial is examining how the diabetes medication liraglutide affects the way insulin detemir works in adults with type 2 diabetes.

Status Completed The study has finished.

Phase Phase 1 Checks safety and dosing in a small group.

Type Interventional (clinical trial)

Design Non-randomized, open-label (no blinding) treatment study

Participants 33 people

Who can join Ages 18+ · all sexes

Timeline Started 2009-03 · est. completion 2009-09

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT00873223 ↗

Description as written by the study sponsor.

This trial is conducted in the United States. The aim of this clinical trial is to investigate whether chronic liraglutide administration affects the mode of action (pharmacokinetics) of insulin detemir

Treatments tested

liraglutide Drug

Subjects will self-inject liraglutide subcutaneously daily during the trial and three euglycemic clamps will be performed: one without liraglutide (insulin detemir alone), the second with only liraglutide treatment and the third with liraglutide and insulin detemir administration
insulin detemir Drug

Subjects will self-inject liraglutide subcutaneously daily during the trial and three euglycemic clamps will be performed: one without liraglutide (insulin detemir alone), the second with only liraglutide treatment and the third with liraglutide and insulin detemir administration

Main thing measured	Insulin detemir pharmacokinetics with and without liraglutide administration
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT00873223 ↗