The Effect of Insulin Detemir in Combination With Liraglutide and Metformin Compared to Liraglutide and Metformin in Subjects With Type 2 Diabetes

NCT00856986 · Completed

Last updated 2026-05-28

This clinical trial tests whether adding insulin detemir to liraglutide and metformin helps lower blood sugar levels in adults with type 2 diabetes over 26 weeks.

Status Completed The study has finished.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) treatment study

Participants 987 people

Who can join Ages 18–84 · all sexes

Timeline Started 2009-03 · est. completion 2010-11

Where 233 sites · Belgium, Canada, France, Germany, Italy, Netherlands, Puerto Rico, Spain, United Kingdom, United States

What this study is testing ClinicalTrials.gov NCT00856986 ↗

Description as written by the study sponsor.

This trial is conducted in Europe and North America. The aim of this clinical trial is to assess and compare the effect of insulin detemir in combination with liraglutide and metformin versus liraglutide and metformin in subjects with type 2 diabetes. Subjects will continue their own pre-trial metformin treatment during the trial.

Treatments tested

liraglutide Drug

Liraglutide 1.8 mg/day for subcutaneous (under the skin) injection.
insulin detemir Drug

Insulin detemir subcutaneous (under the skin) injection once daily. Dose will be titrated (individually adjusted) based on fasting self-measured plasma glucose levels according to a pre-specified algorithm
metformin Drug

Metformin tablets, at least 1500 mg/day

Main thing measured	Mean Change From Randomisation in Glycosylated Haemoglobin A1c (HbA1c) at Week 26.
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT00856986 ↗