The Effect of Liraglutide on Endothelial Function in Subjects With Type 2 Diabetes Mellitus

NCT00620282 · Completed

Last updated 2026-05-28

This clinical trial tested the effect of the medication liraglutide on blood vessel function in adults with type 2 diabetes.

Status Completed The study has finished.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, double-blind treatment study

Participants 49 people

Who can join Ages 40–70 · all sexes

Timeline Started 2008-02 · est. completion 2010-05

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT00620282 ↗

Description as written by the study sponsor.

This trial is conducted in the United States of America (USA). The purpose of the trial is to assess the effect of liraglutide on forearm blood flow in subjects with type 2 diabetes who are on diet and lifestyle changes or treated with metformin alone.

Treatments tested

liraglutide Drug

Stepwise dose increase, s.c. (under the skin) injection, once daily
placebo Drug

Liraglutide placebo, stepwise dose increase, s.c. (under the skin) injection, once daily
glimepiride Drug

Tablets, 1 - 4 mg daily

Main thing measured	Change in Acetylcholine (ACh)-Mediated Forearm Blood Flow (FBF)
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT00620282 ↗