Effect of Liraglutide or Glimepiride Added to Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes

NCT00614120 · Completed

Last updated 2026-05-28

This clinical trial tested whether adding liraglutide or glimepiride to metformin helps control blood sugar levels in adults with type 2 diabetes.

Status Completed The study has finished.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, double-blind treatment study

Participants 929 people

Who can join Ages 18–80 · all sexes

Timeline Started 2008-01 · est. completion 2009-02

Where 50 sites · China, India, South Korea

What this study is testing ClinicalTrials.gov NCT00614120 ↗

Description as written by the study sponsor.

This trial is conducted in Asia. The trial is designed to compare the effect on glycaemic control of liraglutide or glimepiride added to metformin in subjects with type 2 diabetes

Treatments tested

liraglutide Drug

0.6 mg/day, s.c. (under the skin) injection
placebo Drug

Glimepiride placebo, capsules
liraglutide Drug

1.2 mg/day, s.c. (under the skin) injection
liraglutide Drug

1.8 mg/day, s.c. (under the skin) injection
glimepiride Drug

Capsules, 4.0 mg/day
metformin Drug

Tablets, 1.5-2.0 g/day
placebo Drug

Liraglutide placebo, s.c. (under the skin) injection

Main thing measured	Change in Glycosylated Haemoglobin A1c (HbA1c)
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT00614120 ↗