A Study to Compare the Effects of Exenatide and Sitagliptin on Postprandial Glucose in Subjects With Type 2 Diabetes Mellitus

NCT00477581 · Completed

Last updated 2026-05-28

This clinical trial compared how two diabetes medications, exenatide and sitagliptin, affect blood sugar levels after meals in adults with type 2 diabetes.

Status Completed The study has finished.

Phase Phase 4 Monitors a drug already on the market.

Type Interventional (clinical trial)

Design Randomized, triple-blind treatment study

Participants 102 people

Who can join Ages 18–70 · all sexes

Timeline Started 2007-05 · est. completion 2007-09

Where 19 sites · United States

What this study is testing ClinicalTrials.gov NCT00477581 ↗

Description as written by the study sponsor.

This purpose of this study is to compare the effect of exenatide to that of sitagliptin on 2-hour postprandial glucose in subjects with type 2 diabetes mellitus.

Treatments tested

exenatide also known as Byetta Drug

subcutaneous injection (5mcg or 10mcg), twice a day
sitagliptin also known as Januvia Drug

oral administration (100mg), once a day in the morning

Main thing measured	Effect of Exenatide on postprandial glucose
Sponsor	AstraZeneca
Conditions studied	Type 2 Diabetes Mellitus
GLP-1 drugs	exenatide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT00477581 ↗