GLPwatch
Suicidal ideation
1,129 FAERS reports across 6 drugs
Last updated 2026-08-26 06:04 UTCSuicidal ideation means having thoughts about ending one's own life, ranging from a vague wish to die to detailed plans.
Plain-language definition of the term.
Several studies and reviews have examined the association between GLP-1 drugs (including semaglutide and tirzepatide) and suicidal ideation, with mixed findings reported across pharmacovigilance analyses, cohort studies, and systematic reviews.
AI summary of the sources below.
FAERS report counts (as of 2026Q2) reflect voluntary adverse-event reports and cannot establish causation or true frequency; higher counts often track prescription volume. openFDA FAERS ↗
Reports by drug
| Drug | FAERS reports | Quarter |
|---|---|---|
| Ozempic | 461 | 2026Q2 |
| Mounjaro | 342 | 2026Q2 |
| Wegovy | 189 | 2026Q2 |
| Saxenda | 67 | 2026Q2 |
| Rybelsus | 53 | 2026Q2 |
| Xultophy | 17 | 2026Q2 |
Mentioned in FDA labels
Research mentioning suicidal ideation (12)
- Association of semaglutide with risk of suicidal ideation in a real-world cohort.
- Exploring the association between suicidal thoughts, self-injury, and GLP-1 receptor agonists in weight loss treatments: Insights from pharmacovigilance measures and unmasking analysis.
- Glucagon-like Peptide-1 Receptor Agonists and Suicidal Ideation: Analysis of Real-Word Data Collected in the European Pharmacovigilance Database.
- Association of glucagon-like peptide-1 receptor agonists with suicidal ideation and self-injury in individuals with diabetes and obesity: a propensity-weighted, population-based cohort study.
- Glucagon-Like Peptide-1 receptor agonists, dual GIP/GLP-1 receptor agonist tirzepatide and suicidal ideation and behavior: A systematic review of clinical studies and pharmacovigilance reports.
- Semaglutide, suicidal ideation and behaviour: A resting state functional magnetic resonance imaging perspective.
- Risk of suicidal ideation and suicidality among adults prescribed semaglutide for weight management: A population-based cohort study.
- Semaglutide and risk of suicidal ideations.
- Assessing the shadows: A meta-analysis of GLP-1 agonists and suicidal ideation.
- Suicidal Thoughts and Self-injurious Behavior Associated With Glucagon- Like Peptide-1 Receptor Agonists - A Review.
- Depressed mood and suicidal thoughts reporting with GLP-1 receptor agonists in type 2 diabetes: A WHO VigiBase study.
- Semaglutide Linked With Lower Risk of Suicidal Thoughts.