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Repeated semaglutide treatment attenuates cocaine-vs-food choice in male and female rats.
Neuropsychopharmacology · 2026
Last updated 2026-05-28In a study on rats, a 5-day treatment with semaglutide reduced the preference for cocaine over food and also led to significant weight loss. The findings suggest semaglutide may be worth testing in humans as a potential treatment for cocaine use disorder.
AI summary of the abstract below.
| Journal | Neuropsychopharmacology, 2026 |
|---|---|
| Citations | 0 |
| Molecules | semaglutide |
Abstract
The present study determined the effectiveness of the glucagon-like peptide 1 agonist semaglutide to attenuate cocaine-vs-food choice in male and female rats. Repeated 5-day semaglutide treatment decreased cocaine choice and significantly reduced body weight. These preclinical results support the clinical evaluation of semaglutide as a candidate cocaine use disorder medication.
Verbatim abstract via PubMed 41986468 ↗
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