GLPwatch
Cycling GLP-1 receptor agonist treatment induces therapeutic resistance and increased adiposity.
JCI Insight · 2026
Last updated 2026-05-28In a mouse study, stopping and restarting GLP-1 weight-loss drugs led to reduced effectiveness over time and greater fat gain compared to taking the drug continuously. The study did not specify the number of mice or the exact doses used.
AI summary of the abstract below.
| Journal | JCI Insight, 2026 |
|---|---|
| Citations | 0 |
| Molecules | — |
| Conditions studied | Obesity |
Abstract
Stopping and restarting GLP-1 weight-loss drugs in mice made them less effective over time and increased fat gain compared with continuous treatment.
Verbatim abstract via PubMed 41915442 ↗