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Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice.
Cell Metab · 2025
Last updated 2026-05-28In a study on mice, semaglutide was found to affect skeletal muscle mass and strength in ways that were not expected. The research suggests that these effects should be carefully evaluated in humans as well.
AI summary of the abstract below.
| Journal | Cell Metab, 2025 |
|---|---|
| Citations | 12 |
| Relative citation ratio | 4.90 |
| Molecules | semaglutide |
Abstract
Loss of lean mass is a potential concern for semaglutide-induced weight loss. This study indicates that semaglutide has unexpected effects on skeletal muscle mass and strength in mice, demonstrating a need to more carefully assess these effects in humans.
Verbatim abstract via PubMed 40769122 ↗
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