GLPwatch
Intense Uptake of 68 Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.
Clin Nucl Med · 2025
Last updated 2026-05-28A 24-year-old woman with severe low blood sugar was found to have a pancreatic tumor and multiple liver tumors. A scan using a radioactive GLP-1 drug (68 Ga-exendin-4) showed strong uptake in both the pancreatic tumor and all liver tumors, suggesting they were malignant insulinomas. A biopsy confirmed the diagnosis of a high-grade malignant insulinoma.
AI summary of the abstract below.
| Journal | Clin Nucl Med, 2025 |
|---|---|
| Citations | 0 |
| Molecules | — |
| Conditions studied | Type 2 Diabetes |
Abstract
A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68 Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma. This case with extensive glucagon-like peptide-1 receptor (GLP-1R) expression in a high-grade malignant insulinoma highlighted the potential of GLP-1R-targeted PRRT in future clinical studies.
Verbatim abstract via PubMed 40065404 ↗