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The "Weight" for a New Agent Is Almost Over: A Commentary on the Novel Triagonist Retatrutide for Obesity.
J Pharm Technol · 2024
Last updated 2026-05-28Retatrutide is a new drug being studied for obesity that targets three hormones. In phase II trials, participants lost up to 24% of their body weight and nearly 20 cm from their waist. The most common side effects were related to the stomach and intestines. More research is underway to assess its safety and effectiveness.
AI summary of the abstract below.
| Journal | J Pharm Technol, 2024 |
|---|---|
| Citations | 0 |
| Relative citation ratio | 0.00 |
| NIH percentile | 0 |
| Molecules | retatrutide |
| Conditions studied | Obesity |
Abstract
Retatrutide, a hormone receptor agonist targeting glucagon, glucagon-like peptide 1, and glucose-dependent insulinotropic polypeptide, is being developed to treat obesity. A literature review from April 2019 to April 2024 included such terms as "retatrutide," "LY3437943," "overweight," and "obesity." Phase I proof-of-concept studies led to phase II trials showing up to 24% body weight reduction and nearly 20 cm waist circumference reduction. The most common adverse effects were gastrointestinal. Ongoing phase II and III studies aim to further evaluate the safety and efficacy of retatrutide as a novel triagonist for obesity treatment.
Verbatim abstract via PubMed 39507873 ↗
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