GLPwatch
Tirzepatide-Associated Colonic Ischemia.
ACG Case Rep J · 2024
Last updated 2026-06-21| Journal | ACG Case Rep J, 2024 |
|---|---|
| Citations | 6 |
| Relative citation ratio | 1.20 |
| NIH percentile | 57 |
| Molecules | tirzepatide |
Abstract
The use of the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist tirzepatide has markedly increased for the treatment of weight loss and management of diabetes mellitus. Gastrointestinal adverse effects of GLP-1/GIP agonist therapy, including nausea, vomiting, and constipation, are common. We report a case of colonic ischemia in a 62-year-old woman which developed in association with the use of tirzepatide for weight loss. This report highlights a potential risk relationship between GLP-1/GIP agonist therapy and colonic ischemia and identifies risk factors that should be considered before prescribing tirzepatide.
Verbatim abstract via PubMed 39507503 ↗
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