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Hot Water Eliminates the Bitter Taste of Oral Semaglutide: A Report of Four Cases.
Intern Med · 2024
Last updated 2026-05-28Four patients taking oral semaglutide for type 2 diabetes reported that drinking hot water at temperatures between 46.0°C and 52.0°C eliminated the drug's bitter taste. Their blood sugar control remained within the target range during this method.
AI summary of the abstract below.
| Journal | Intern Med, 2024 |
|---|---|
| Citations | 2 |
| Relative citation ratio | 0.38 |
| NIH percentile | 23 |
| Molecules | semaglutide |
| Conditions studied | Type 2 Diabetes, Obesity |
Abstract
Semaglutide is a well-designed drug with a special coating that allows for oral administration to patients with type 2 diabetes mellitus. However, patients taking oral semaglutide complain of its bitter taste. We therefore considered suggesting that patients take oral semaglutide with hot water. When the hot water temperature was increased to above 46.0°C but below 52.0°C, no bitter taste was perceived, with the daily mean interstitial glucose level remaining at the target range. Taking oral semaglutide with hot water helps reduce its bitter taste.
Verbatim abstract via PubMed 38220187 ↗
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