Liraglutide combined with metformin treatment for obese people with type 2 diabetes mellitus: a systematic review and meta-analysis.

AIM: To assess clinical efficacy and safety of liraglutide combined with metformin (LMT) in obese patients with type 2 diabetes (ODP) by conducting a meta-analysis of randomized controlled trials (RCTs). METHODS: PubMed, EMBASE, Cochrane Library, CNKI, CNKI, and VIP databases were systematically searched for randomized controlled trials (RCTs) through January 1, 2015 to investigate the effectiveness of liraglutide combined with metformin treatment (LMT) in obesity patients with type 2 diabetes (ODP). Meta-analysis (using generic inverse variance random effects model) was performed when there were two or more studies reporting on the same evaluation indicators. Review Manager V.5.3 was used to perform the meta-analysis. RESULTS: A total of 1289 participants from 15 RCTs were selected for the final meta-analysis. A synthesis of current evidence of LMT for treating ODP was provided in this protocol. CONCLUSION: This review will offer insights for future research and provide reference for LMT treatment for ODP.