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Evaluation of NAFLD fibrosis, FIB-4 and APRI score in diabetic patients receiving exenatide treatment for non-alcoholic fatty liver disease.

Sci Rep · 2022

Last updated 2026-05-28

In a study of 50 people with type 2 diabetes and fatty liver disease, researchers measured three scores (NFS, FIB4, and APRI) that estimate liver scarring before and after 6 months of treatment with the GLP-1 drug exenatide. After 6 months, two of the scores (NFS and APRI) dropped significantly, and blood sugar control and body weight also improved.

AI summary of the abstract below.

JournalSci Rep, 2022
Citations12
Relative citation ratio1.03
NIH percentile51
Molecules exenatide
Conditions studied Type 2 Diabetes, Mash

Abstract

There is a closely relationship between the development and progression of nonalcoholic fatty liver disease (NAFLD) or metabolic associated fatty liver disease (MAFLD) and obesity and diabetes. NAFLD fibrosis scores should be routinely used to rule out patients with advanced fibrosis. High scores may help identify patients at higher risk of all causes andliverrelated morbidity and mortality. The aim of this study was to investigate the association between exenatide and fibrosis scores. The effect of exenatide treatment on fibrosis scores was evaluated in type 2 diabetes mellitus (DM) patients with MAFLD. Evaluation was made of 50 patients with type 2 DM and MAFLD. The NFS, FIB4 and APRI scores were calculated before and after 6 months of treatment. After 6 months of exenatide treatment, the NFS and APRI scores were determined to have decreased significantly. Exenatide was observed to control blood glucose, reduce body weight and improve fibrosis scores in MAFLD patients with type 2 diabetes.

Verbatim abstract via PubMed 34997159 ↗

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