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Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials.
BMC Endocr Disord · 2019
Last updated 2026-05-28A review of 18 clinical trials with 13,662 participants found that liraglutide, a GLP-1 drug, lowered systolic blood pressure by an average of 3.18 mmHg compared to a placebo. The effect on diastolic blood pressure was small and depended on the dose: a 3.0 mg/day dose slightly reduced it by 1.46 mmHg, while a 1.8 mg/day dose slightly increased it by 0.47 mmHg. The blood pressure-lowering effect was not significant when the treatment lasted over one year.
AI summary of the abstract below.
| Journal | BMC Endocr Disord, 2019 |
|---|---|
| Citations | 39 |
| Relative citation ratio | 1.68 |
| NIH percentile | 68 |
| Molecules | liraglutide |
| Conditions studied | Cardiovascular Risk Reduction, Obesity, Type 2 Diabetes |
Abstract
BACKGROUND: Several clinical trials have studied the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycometabolism and cardiovascular risk factors since they were identified. Because of their cardiovascular benefits and efficacy in lowering glucose, GLP-1RAs are becoming increasingly important in clinical therapy for patients with or without pathoglycaemia. The aim of this study was to assess the effect of the GLP-1RA liraglutide on blood pressure based on randomised controlled trials (RCTs).
METHODS: We searched PubMed for RCTs published from 2009 to 2018 comparing the effect of liraglutide on blood pressure with that of placebo in individuals with or without pathoglycaemia. RCTs in humans that included data describing blood pressure changes from baseline to the end of the trial were selected for inclusion in the meta-analysis.
RESULTS: A total of 18 RCTs that enrolled 7616 individuals in the liraglutide group and 6046 individuals in the control group were included in this meta-analysis. Compared with placebo, liraglutide reduced systolic blood pressure (SBP) by 3.18 mmHg (95% CI -4.32, - 2.05), P < 0.00001, but had no significant effect on diastolic blood pressure (DBP). Subgroup analysis showed that the degree of reduction in SBP was associated with the dose of liraglutide but that significance disappeared when the intervention lasted over 1 year. Liraglutide 3.0 mg/d significantly reduced DBP by 1.46 mmHg (95% CI -2.61, 0.32), P = 0.01, but liraglutide 1.8 mg/d slightly increased DBP by 0.47 mmHg (95% CI 0.11, 0.83), P = 0.01, compared with placebo.
CONCLUSIONS: This meta-analysis demonstrated that liraglutide significantly reduced SBP in individuals with or without pathoglycaemia compared with placebo, but the difference was no longer significant when the intervention lasted over 1 year. Moreover, the effect of liraglutide on blood pressure is associated with the dose. This finding may provide additional evidence for cardiovascular protection.
Verbatim abstract via PubMed 30616638 ↗
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