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A sensitive method for the quantitation of the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in plasma using microfluidics chromatography tandem MS.

Bioanalysis · 2018

Last updated 2026-05-28

Researchers developed a lab test to measure liraglutide, a GLP-1 drug, in blood samples. The test can detect levels between 10 and 5,000 nanograms per milliliter and was used to study how the drug behaves in monkeys after a 30 microgram per kilogram dose, showing it stays in the body for about 6.6 hours.

AI summary of the abstract below.

JournalBioanalysis, 2018
Citations6
Relative citation ratio0.22
NIH percentile14
Molecules liraglutide

Abstract

AIM: An LC-MS/MS assay for the quantitation of liraglutide, a peptide-based injectable glucagon-like peptide-1 receptor agonist, has been developed as a convenient alternative to the enzyme-linked immunosorbent assay, and used to characterize liraglutide pharmacokinetics in cynomolgus monkeys. RESULTS: Assay calibration curves exhibited a linear dynamic range of 10-5000 ng/ml and correlation coefficient ≥0.98. Following a 30 μg/kg intravenous dose, liraglutide demonstrated low plasma clearance and distribution volume, which led to a terminal half-life of 6.59 h in monkeys. CONCLUSION: The dynamic range of our LC-MS/MS assay provides sufficient coverage of the average efficacious liraglutide concentrations in human plasma, and can be used for pharmacokinetics/pharmacodynamics studies in animals and potentially in humans.

Verbatim abstract via PubMed 29516741 ↗

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