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Insulin Glargine/Lixisenatide: A Review in Type 2 Diabetes.
Drugs · 2017
Last updated 2026-05-28Insulin glargine/lixisenatide is a once-daily injection combining two diabetes medications for adults with type 2 diabetes whose blood sugar is not well controlled. In two 30-week studies with over 1,000 adults, this combination improved blood sugar control and helped with weight loss without increasing the risk of low blood sugar. The treatment was generally well tolerated when used alongside metformin.
AI summary of the abstract below.
| Journal | Drugs, 2017 |
|---|---|
| Citations | 11 |
| Relative citation ratio | 0.38 |
| NIH percentile | 23 |
| Molecules | lixisenatide |
| Conditions studied | Type 2 Diabetes |
Abstract
Subcutaneous insulin glargine/lixisenatide (Suliqua™) is a titratable, fixed-ratio combination of a long-acting basal insulin analogue and a glucagon-like peptide-1 (GLP-1) receptor agonist for the treatment of adult patients with inadequately controlled type 2 diabetes. Once-daily insulin glargine/lixisenatide, in combination with metformin, provided effective glycaemic control and was generally well tolerated in the 30-week, multinational, phase 3 LixiLan-O and LixiLan-L trials in insulin-naive and -experienced adult patients with inadequately controlled type 2 diabetes. Although long-term clinical experience with this fixed-ratio combination is currently lacking, given its convenient once-daily regimen and beneficial effects on glycaemic control and bodyweight loss in the absence of an increase in the incidence of hypoglycaemia, insulin glargine/lixisenatide is an emerging option for the treatment of adult patients with type 2 diabetes to improve glycaemic control when this has not been provided by metformin alone or metformin combined with another OAD or basal insulin.
Verbatim abstract via PubMed 28667587 ↗
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