GLPwatch
Involvement of Glucagon-Like Peptide-1 in the Regulation of Selective Excretion of Sodium or Chloride Ions by the Kidneys.
Bull Exp Biol Med · 2017
Last updated 2026-09-22In rats, GLP-1 levels rose 5 minutes after drinking salt solutions, similar to after drinking glucose. The GLP-1 drug exenatide increased sodium and chloride excretion when salt was given by injection, and it increased chloride excretion while reducing sodium loss when a different salt solution was used.
AI summary of the abstract below.
| Journal | Bull Exp Biol Med, 2017 |
|---|---|
| Citations | 6 |
| Relative citation ratio | 0.22 |
| NIH percentile | 14 |
| Molecules | — |
| Conditions studied | Chronic Kidney Disease |
Abstract
An increase of total glucagon-like peptide-1 (GLP-1) concentration in the plasma in rats was revealed 5 min after oral, but not intraperitoneal administration of NaCl or Trizma HCl solutions. The increase in GLP-1 level was similar to that after oral glucose administration. After intraperitoneal administration of 2.5% NaCl, GLP-1 mimetic exenatide accelerated natriuresis and urinary chloride excretion. Under conditions of normonatriemia and hyperchloremia induced by injection of 6.7% Trizma HCl, exenatide stimulated chloride excretion and reabsorption of sodium ions in the kidneys. These findings suggest that GLP-1 participates in selective regulation of the balance of sodium and chloride ions.
Verbatim abstract via PubMed 28243920 ↗