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Efficacy of lixisenatide in patients with type 2 diabetes: A post hoc analysis of patients with diverse β-cell function in the GetGoal-M and GetGoal-S trials.
J Diabetes Complications · 2016
Last updated 2026-05-28In a study of 437 people with type 2 diabetes taking lixisenatide 20 micrograms once daily, blood sugar control improved after 24 weeks regardless of how well their insulin-producing cells worked at the start. On average, a key blood marker (HbA1c) dropped by about 0.83% to 0.99%, and after-meal blood sugar fell by 4.3 to 7.9 mmol/L across all groups. No severe low blood sugar events were reported during the study.
AI summary of the abstract below.
| Journal | J Diabetes Complications, 2016 |
|---|---|
| Citations | 15 |
| Relative citation ratio | 0.63 |
| NIH percentile | 35 |
| Molecules | lixisenatide |
| Conditions studied | Type 2 Diabetes |
Abstract
AIMS: To evaluate the impact of β-cell function on the efficacy of lixisenatide, a once-daily prandial glucagon-like peptide-1 receptor agonist, in patients with type 2 diabetes (T2D).
MATERIALS AND METHODS: In this post hoc analysis, patients from the Phase 3 GetGoal-M and GetGoal-S clinical trials randomized to lixisenatide 20μg once daily were stratified into quartiles by baseline β-cell function, as measured by the secretory units of islet in transplantation (SUIT) index.
RESULTS: Patients (N=437) were distributed evenly among SUIT index quartiles 1 to 4 (lowest to highest β-cell function). Clinical outcomes improved from baseline across all SUIT quartiles; mean changes at week 24 were: glycated hemoglobin (HbA1c; % [mmol/mol]), -0.99 (-10.8), -0.87 (-9.5), -0.86 (-9.4), -0.83 (-9.1); and postprandial plasma glucose (PPG; mmol/L), -7.9, -5.6, -5.5, -4.3 (overall effect P<0.0001). Furthermore, postprandial glucagon was reduced in all SUIT quartiles, while insulinogenic index improved only in patients with higher baseline SUIT (overall effect P=0.0286). No severe symptomatic hypoglycemic events were reported.
CONCLUSIONS: Lixisenatide treatment resulted in reductions in HbA1c and PPG levels across all SUIT quartiles. This suggests that non-insulin-related actions of lixisenatide contribute to improved glycemic control in T2D.
Verbatim abstract via PubMed 27267268 ↗
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