GLPwatch

Differing effects of liraglutide on gastric emptying in Japanese patients with type 2 diabetes.

Diabetes Obes Metab · 2014

Last updated 2026-05-28

In a study of 16 Japanese patients with type 2 diabetes, liraglutide slowed stomach emptying in 7 patients (delayers) by an average of 31 minutes, while it had little to no effect in the other 9 patients (non-delayers). The delayers also showed a larger early drop in blood sugar levels without a corresponding increase in insulin. The results suggest liraglutide’s impact on stomach emptying varies among individuals.

AI summary of the abstract below.

JournalDiabetes Obes Metab, 2014
Citations13
Relative citation ratio0.48
NIH percentile28
Molecules liraglutide
Conditions studied Type 2 Diabetes

Abstract

This study was performed to clarify the influence of liraglutide on gastric emptying in Japanese patients with type 2 diabetes. In 16 patients, the [(13) C]-acetate breath test was performed to compare gastric emptying before and after liraglutide treatment. We found two patterns of response, with gastric emptying being delayed by liraglutide in seven patients (delayers) and not delayed in nine patients (non-delayers). The mean increase of the maximum gastric emptying time was 31 ± 4 min (p < 0.01 vs. baseline) in the delayers, while it was only 2 ± 3 min (p = 0.60 vs. baseline) in the non-delayers. The delayers showed a greater early decrease of AUC-PG from 0 to 60 min, despite no increase of the plasma insulin level compared with non-delayers. In conclusion, the effect of liraglutide treatment on gastric emptying shows heterogeneity, and patients can be classified as delayers or non-delayers.

Verbatim abstract via PubMed 24320758 ↗

Related research