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[The effect of exenatide analogs on hydruretic function of rat kidney under water load].

Eksp Klin Farmakol · 2012

Last updated 2026-05-28

In a study on rats, a drug called exenatide and two of its modified versions (analog I and analog II) were injected at a dose of 0.05 nmol per 100 grams of body weight. All three increased urine production and the excretion of sodium, magnesium, and potassium, but only exenatide and analog I also increased the excretion of solute-free water, which may be relevant for kidney function.

AI summary of the abstract below.

JournalEksp Klin Farmakol, 2012
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Molecules exenatide

Abstract

Injection (0.05 nmol/100 g b.w.) of exenatide or its amino-acid-substituted synthetic analogs I (substitution at positions 14 and 39) and II (substitution at positions 14, 35, and 39) led to an increase in diuresis and excretion of sodium, magnesium and potassium, but only exenatide caused the excretion of solute free water. In experiments with 1% water load, only exenatide analog I stimulated the solute free water excretion. These features of exenatide and its analogs show the possibility of searching for substances with various power of action upon ion and water excretion by the kidney, which may have a clinical significance.

Verbatim abstract via PubMed 23323326 ↗

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